Epitope Mismatch Algorithm


HLA-EMMA is a software tool designed to perform HLA class I and class II compatibility analysis on the amino acid level. HLA-EMMA predicts & analyses HLA antibody formation.


HLA-EMMA was developed using several public databases and open source software packages.
You will find more information about the websites, tools and articles in the source section.

About us

HLA-EMMA was developed in the Transplantation Immunology Laboratory, dept. of Immunology, LUMC Leiden, under supervision of Dr. Sebastiaan Heidt, Dr. Dave Roelen and Prof. Dr. Frans Claas.


By using this website you agree that its contents are used for research purposes and not for making clinical decisions regarding patient care and donor selection. Whereas we use our best efforts to provide high-quality software and verify that the data contained therein have been selected on basis of sound scientific judgement, it does not offer any guarantee about its accuracy.

When HLA-EMMA is used for scientific research that is to be published in a scientific journal or used in a presentation, please cite:

Kramer et al., HLA 2020.

PMID: 32227681